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+--- Thread: small interfering RNA (siRNA)-based therapeutics (/thread-8134.html)
small interfering RNA (siRNA)-based therapeutics - NightskyeB4Dawn - 01-31-2022
Sharing just in case anyone else found this as interesting as I did.
Of course, must of us will not know what has hit us until the genes they are silencing make us deaf, dumb, and blind.
Wait a minute.............
Quote:More than two decades after the natural gene-silencing mechanism of RNA interference was elucidated, small interfering RNA (siRNA)-based therapeutics have finally broken into the pharmaceutical market. With three agents already approved and many others in advanced stages of the drug development pipeline, siRNA drugs are on their way to becoming a standard modality of pharmacotherapy.
The majority of late-stage candidates are indicated for rare or orphan diseases, whose patients have an urgent need for novel and effective therapies. Additionally, there are agents that have the potential to meet the need of a broader population. Inclisiran, for instance, is being developed for hypercholesterolemia and has shown benefit in patients who are uncontrolled even after maximal statin therapy.
This review provides a brief overview of mechanisms of siRNA action, physiological barriers to its delivery and activity, and the most common chemical modifications and delivery platforms used to overcome these barriers. Furthermore, this review presents comprehensive profiles of the three approved siRNA drugs (patisiran, givosiran, and lumasiran) and the seven other siRNA candidates in Phase 3 clinical trials (vutrisiran, nedosiran, inclisiran, fitusiran, teprasiran, cosdosiran, and tivanisiran), summarizing their modifications and delivery strategies, disease-specific mechanisms of action, updated clinical trial status, and future outlooks.
https://www.sciencedirect.com/science/article/abs/pii/S0006295221000289
RE: small interfering RNA (siRNA)-based therapeutics - guohua - 01-31-2022
(01-31-2022, 05:48 PM)NightskyeB4Dawn Wrote: Sharing just in case anyone else found this as interesting as I did.
Of course, must of us will not know what has hit us until the genes they are silencing make us deaf, dumb, and blind.
Wait a minute.............
Quote:More than two decades after the natural gene-silencing mechanism of RNA interference was elucidated, small interfering RNA (siRNA)-based therapeutics have finally broken into the pharmaceutical market. With three agents already approved and many others in advanced stages of the drug development pipeline, siRNA drugs are on their way to becoming a standard modality of pharmacotherapy.
The majority of late-stage candidates are indicated for rare or orphan diseases, whose patients have an urgent need for novel and effective therapies. Additionally, there are agents that have the potential to meet the need of a broader population. Inclisiran, for instance, is being developed for hypercholesterolemia and has shown benefit in patients who are uncontrolled even after maximal statin therapy.
This review provides a brief overview of mechanisms of siRNA action, physiological barriers to its delivery and activity, and the most common chemical modifications and delivery platforms used to overcome these barriers. Furthermore, this review presents comprehensive profiles of the three approved siRNA drugs (patisiran, givosiran, and lumasiran) and the seven other siRNA candidates in Phase 3 clinical trials (vutrisiran, nedosiran, inclisiran, fitusiran, teprasiran, cosdosiran, and tivanisiran), summarizing their modifications and delivery strategies, disease-specific mechanisms of action, updated clinical trial status, and future outlooks.
https://www.sciencedirect.com/science/article/abs/pii/S0006295221000289
Okay, now that is Scary!
And very possibly the Truth!
RE: small interfering RNA (siRNA)-based therapeutics - Kenzo - 01-31-2022
Sounds just like...Rockefeller medicine
Why they call it small interfering ? i would not say it`s small if they change RNA .
Yeeh, i agree sounds dangerous . Leave my RNA intact, and DNA also, im a human being who wants to be full human
RE: small interfering RNA (siRNA)-based therapeutics - Ninurta - 01-31-2022
I can see this going south in a hell of a hurry.
When you get right down to the molecular, genetic level, very few, if any, human traits are controlled by a single gene. What makes you "you" is the effects of the combination of a multiplicity of genes, acting together. If you turn off one gene to control a disease, what OTHER traits might that gene have a hand in contributing to and controlling as well?/ What else might they be changing by turning that one gene off to control a disease?
Nope, nope, nope. that could get hairy, and fraught with unintended consequences.
.
RE: small interfering RNA (siRNA)-based therapeutics - GeauxHomeLittleD - 01-31-2022
I've noticed recently that you must be vigilant when it comes to any sort of medical treatment to be sure of what you are getting. The covid vaxx has opened the door to Frankenstein's laboratory. For example, the new shingles vaccines are MRna gene therapy shots which you only find out by reading the extremely fine print. There are hundreds (if not more) of new treatments for everything under the sun that are using the new MRna technology. They are doing numerous studies in our area due to being a big hospital and university town with MRna based treatments for everything from migraines and arthritis to MS and cancers.
It is extremely scary to me.
I think I would just rather check out naturally than allow Frankenstein to fiddle with my Dna.
RE: small interfering RNA (siRNA)-based therapeutics - NightskyeB4Dawn - 02-01-2022
(01-31-2022, 11:46 PM)GeauxHomeLittleD Wrote: I think I would just rather check out naturally than allow Frankenstein to fiddle with my Dna.
100% agree with you there.
I try to go the natural route whenever I can. I consume ginger, a lot of fresh raw ginger tea, during the day. A turmeric, lemon, black pepper, coconut water drink every morning, and at bedtime. And fresh star fruit a couple times a day. I also use CBD ointment to my joints, and I either eat or smoke it before bed. It has me still walking, and I was able to forego surgery on my knees, spine, and back.
I fully trust natural over any medical or any man made pharmaceutical treatment.